Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

マウス
系統名:C57BL/6Smoc-Zmynd12em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
マウス
系統名:C57BL/6Smoc-Zmynd15em1(flox)Smoc
維持形態:Sperm cryopreservation | SMOC番号:NM-CKO-232458
マウス
系統名:C57BL/6Smoc-Zmynd19em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
マウス
系統名:C57BL/6Smoc-Zmynd8em1(flox)Smoc
維持形態:Sperm cryopreservation | SMOC番号:NM-CKO-2105568
マウス
系統名:C57BL/6Smoc-Znfx1em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
マウス
系統名:C57BL/6Smoc-Znhit1em1(flox)Smoc
維持形態:Developing | SMOC番号:NM-CKO-241763
マウス
系統名:C57BL/6Smoc-Znhit2em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
マウス
系統名:C57BL/6Smoc-Znhit3em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
マウス
系統名:C57BL/6Smoc-Znhit6em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
マウス
系統名:C57BL/6Smoc-Znrd1em1(flox)Smoc
維持形態:Developing | SMOC番号:TBD
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