hOX40(2)/hOX40L

系統名

C57BL/6Smoc-Tnfrsf4em1(hTNFRSF4)Tnfsf4em2(hTNFSF4)/Smoc

SMOC番号

NM-HU-200263

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol

Synonyms

Ath1， gp34， Ath-1， Ox40l， TXGP1， CD134L， OX-40L， Tnlg2b， Txgp1l，Ox40， ACT35， CD134， Ly-70， Txgp1， TXGP1L

NCBI ID

22164，22163

MGI ID

104511，104512

Ensembl ID

ENSMUSG00000026700，ENSMUSG00000029075

Pubmed

Human Ortholog

TNFSF4，TNFRSF4

説明

hTNFSF4（NM-HU-200005）was crossed with hOX40(2)（NM-HU-00041）to generate hOX40(2)/hOX40L mice

表現型データ

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Fig1. OX40 expression on CD4+ T cells in spleen in hOX40 KI mice.

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Fig2. OX40 expression on Treg cells in spleen in hOX40 KI mice. 

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Fig3. Detection of hOX40L expression on stimulated APCs in hOX40/hOX40L dKI mice.

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Fig4. OX40 antibody showed dose-dependent anti-tumor activity in human OX40 knock-in mice bearing MC38 tumors.(The OX40 antibody was obtained from Innoventbio)

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