hLILRB4

系統名

C57BL/6Smoc-Lilrb4aem1(hLILRB4 )Smoc

SMOC番号

NM-HU-210024

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Lilrb4a

説明

The endogenous mice Lilrb4a gene was completely or partially replaced by human LILRB4 gene via CRISPR/Cas9 mediated recombination.
応用分野:inmmue therapy;drug screening

表現型データ

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Fig1. Strain specific hLILRB4 expression analysis in heterozygous hLILRB4 mice by flow cytometry. Bone marrow derived Myeloid cells, Macrophages, DC, T cells and B cells were collected and analyzed by flow cytometry with species- specific anti-hLILRB4 antibody. hLILRB4 was expressed in Myeloid cells including Macrophages and DC of heterozygous hLILRB4 mice, and not expressed in T and B cells.

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Fig2. Strain specific hLILRB4 expression analysis in heterozygous hLILRB4 mice by flow cytometry. Spleen derived Myeloid cells, Macrophages, DC, T cells and B cells were collected and analyzed by flow cytometry with species- specific anti-hLILRB4 antibody. hLILRB4 was expressed in Myeloid cells including Macrophages and DC of heterozygous hLILRB4 mice, and detectable in a small proportion of T and B cells.


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