hFCRN(NMG)

系統名

NOD.Cg-PrkdcscidIl2rgem1Fcgrtem2(FCGRT)Smoc

SMOC番号

NM-NSG-020

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Fcgrt

Synonyms

FcRn

NCBI ID

14132

MGI ID

103017

Ensembl ID

ENSMUSG00000003420

Pubmed

Fcgrt

Human Ortholog

FCGRT

説明

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.
応用分野：Immunotherapy,cancer research,drug screening

表現型データ

image.png

Fig.1 Detection of FCRN expression in kidney by RT-PCR. 

Wild type: only one band at 181 bp with primers F1/R1(mFcgrt);

Heterozygous: one band at 181 bp with primers F1/R1(mFcgrt) and one band at 310 bp with primers F2/R2(hFCGRT). 

Abbr. M, DNA marker; HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human FCRN expression in hFCRN (NMG) mice by WB. 

Abbr. M, marker; WT1, wild type, NOD-Scid; WT2, wild type, NMG; HE, heterozygous; PC, positive control, hFCRN (NM-HU-190070).


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