Lgr5-2A-DreERT2

系統名

C57BL/6JSmo-Lgr5em1(2A-DreERT2)Smoc

SMOC番号

NM-KI-200178

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Lgr5

説明

A 2A-DreERT2 expression cassette was knocked into the Lgr5 gene stop codon site.
応用分野:Dre recombinase tool

表現型データ

image.png

Fig1. Dre mediated recombination in liver of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Hepatocyte expressing tdTomato(red) after tamoxifen induction of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. (see the reference). 

image.png

Fig2. Dre mediated recombination in colon of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Lgr5-2A-DreERT2 43T,46.jpg

Fig3. Detection of tdTomato(red) in various tissues of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. 

Tissues expressing tdTomato after tamoxifen induction included the large intestine, small intestine, liver, stomach, and skin. In contrast, no significant fluorescent expression was observed in the brain, spinal cord, esophagus, muscle, vagina, or reproductive system of the mice following tamoxifen induction. (38-days old, female) (For more detailed information please contact our technical advisor.) 



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