Nkx3-1-IRES-CreERT2

系統名

C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc

SMOC番号

NM-KI-200071

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Nkx3-1

Synonyms

Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe

Chromosome

14

NCBI ID

18095

MGI ID

97352

Ensembl ID

ENSMUSG00000022061

Pubmed

Nkx3-1

Human Ortholog

NKX3-1

説明

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.
応用分野：This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. This strain is useful in studying prostate.

表現型データ

image.png

Fig. 1 CreERT2-mediated recombination in the prostate of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the prostate lumen cells of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

image.png

Fig. 2 Detection of tdTomato(red) in various tissues of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the prostate and individual cells of kidney. TdTomato can not be detected in the brain, thymus, retina, lung, liver, stomach, salivary gland, pancreas, colon, intestine, spleen, skin, testis and epididymis. (For more detailed information please contact our technical advisor.)


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