hMAPT-P301S

系統名

C57BL/6Smoc-Maptem1hMAPT-P301SSmoc

SMOC番号

NM-KI-233262

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Mapt

Synonyms

Tau; Mtapt; AI413597; AW045860

Chromosome

11

NCBI ID

17762

MGI ID

97180

Ensembl ID

ENSMUSG00000018411

Pubmed

Mapt

Human Ortholog

MAPT

説明

These strains carry a P301S mutation of hMAPT gene.

表現型データ

image.png

Fig.1 Detection of hMAPT-P301S expression in brain by RT-PCR. 

Wild type: only one band at 245 bp with primers F1/R1 (mMapt);

Heterozygous: one band at 245 bp with primers F1/R1 (hMAPT).

Abbr. M, DNA marker;  HE, heterozygous; WT, wild type.

image.png

Fig.2 Sequencing results of the MAPT locus in the wild type and heterozygous hMAPT-P301S mice.

image.png

Fig.3 Detection of Phospho-Tau expression in brain in hMAPT-P301S mice by WB. The relative gray values to GAPDH were quantitated by densitometry using ImageJ software.

Abbr. M, marker; WT, wild type; HO, homozygous.

Note. UnPaired t-test, *P < 0.01.


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