hC5
系統名
C57BL/6Smoc-Hcem1(hC5)Smoc
SMOC番号
NM-HU-2000013
維持形態
Repository Live
遺伝子の概要
Gene Symbol
説明
The endogenous mouse C5a gene was replaced by human C5 gene.
表現型データ
Fig 1. Detection of C5 expression by RT-PCR.
Wild type: only one band at 167 bp with primers F2/R2(mC5);
Homozygous: only one band at 337 bp with primers F1/R1(hC5).
Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig 2. Analysis of humanized C5 and humanized C5a expression in serum in the humanized C5 mouse by ELISA.
The homozygous hC5 KI mice were treated with LPS or NS (3mg/kg, i.p.) for 6 hours.
Fig 3. Detection of hC5 expression in eyes in hC5 KI mice by IF (n=3/group).
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
詳細Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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