R26-pAPOE-hCYP3A4(FVB)
系統名
FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
SMOC番号
NM-KI-18032
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
Gt(ROSA)26Sor
説明
This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.
応用分野：metabolism
*Literature published using this strain should indicate: R26-pAPOE-hCYP3A4(FVB) mice (Cat. NO. NM-KI-18032) were purchased from Shanghai Model Organisms Center, Inc..
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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